Endocrine Abstracts

Fat-derived adipokine genes that modulate metabolic and inflammatory responses, such as resistin (rstn) and fasting-induced adipose factor (fiaf), are also expressed in mouse brain and pituitary gland. We, and others, reported that central fiaf and rstn mRNA levels were increased following a brain injury-induced inflammatory response, and central injection of resistin reduced food intake and increased hepatic glucose production. Since LPS-induced en...

Kisspeptins, peptide products of the KiSS-1 gene, are pleiotropic hormones best recognized as novel regulators of puberty onset and the reproductive system. Thus, the hypothalamus expresses both KiSS-1 and its receptor, GPR54. Hypothalamic KiSS-1 is attenuated by food restriction (72 h fast),and this provides a plausible link between negative energy balance and the disruption of reproductive function. Hypothalamic KiSS-1 mRNA levels are also reduced...

The guidelines for management of prolactinomas (PRLoma) during pregnancy are mostly based on retrospective evidence or expert opinion. We conducted a survey of four Canadian provinces (NS, NB, PEI and BC) to assess the current trends in management of PRLoma during pregnancy. A case-based electronic questionnaire was sent to all practicing endocrinologists, with 3 cases of varying severity ranging from a micro PRLoma to a large macroPRLoma compressing the optic chiasm. A total ...

Aims/hypothesis: Resistin could be implicated in the mechanism of insulin resistance and recent evidence suggests this occurs, in part, via a brain-dependent pathway. Given the emerging role of hypothalamic AMP-activated protein kinase (AMPK) in the modulation of appetite and glucose levels, we hypothesized that its activity would be modulated by resistin. To verify such a pathway, we employed the N-1 hypothalamic neuronal cell line, which expresses a variety of neuropeptides ...

Background: Patients with acromegaly responding to injectable somatostatin receptor ligands (SRL) are often treated for decades without deterioration of biochemical response (except for routine fluctuations in IGF-I control), unless there are changing clinical circumstances such as persistent or recurrent tumor growth. Oral octreotide capsules (OOC) have been formulated as a potential therapy for acromegaly and the safety and efficacy was evaluated in the CHIASMA OPTIMAL pivot...

Background: Most patients responding to injectable somatostatin receptor ligands exhibit IGF-I variability around the upper limit of normal (ULN) during long-term follow up. These fluctuations are thought to result from assay variability, nutrition, comorbid conditions, concomitant medications and other unknown factors. The magnitude and factors affecting this variability arenot well understood in patients with acromegaly treated with injectable SRLs.Met...